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Iman Sami-Zakhari, MD

Additional Degrees or Certifications:
Member of the Royal College of Physicians, UK
Board Certifications:
American Board of Pediatrics/Pulmonology
American Board of Pediatrics/Sleep Medicine
Areas of Clinical Interest:
Asthma, cystic fibrosis, sickle cell lung disease, rare lung disorders (primary ciliary dyskinesia and interstitial lung disease) and sleep, with specific research in cystic fibrosis

Fellowship: Children’s National Medical Center (1985)
Internship: University of Khartoum Faculty of Medicine (1979)
Residency: Children's Hospital of the King's Daughters and Eastern Virginia Medical School
Medical School: University of Khartoum and University of Liverpool, UK
Undergraduate: University of Khartoum

Awards & Recognition:

Top Doctors Recognition: Northern Virginia Magazine
Director, Pediatric Pulmonary Fellowship Program, Children's National Hospital, Washington, DC

Clinic Locations: Fairfax

Keystone Publications:

Therapeutic beta-lactam dosages and broad-spectrum antibiotics are associated with reductions in microbial richness and diversity in persons with cystic fibrosis. Sci Rep 2023

Using metabolic potential within the airway microbiome as predictors of clinical state in persons with cystic fibrosis. Front. Med. 2023

Impact of Antibiotics on the Lung Microbiome and Lung Function in Children with Cystic Fibrosis 1 Year After Hospitalization for an Initial Pulmonary Exacerbation. Open Forum Infectious Diseases 2022

Measuring the Impact of an Empiric Antibiotic Algorithm for Pulmonary Exacerbation in Children and Young Adults with Cystic Fibrosis. Pediatr Pulmonol 2022

Importance of Beta-Lactam Pharmacokinetics and Pharmacodynamics on the Recovery of Microbial Diversity in the Airway of Persons with Cystic Fibrosis. J Investig Med 2021

Inflammation in children with Cystic Fibrosis: contribution of bacterial production of long-chain fatty acids. Pediatr Res 2021

Impact of Anaerobic Antibacterial Spectrum on Cystic Fibrosis Airway Microbiome Diversity and Pulmonary Function. Pediatr Infect Dis J 2021

Airway microbial diversity is decreased in young children with cystic fibrosis compared to healthy controls but improved with CFTR modulation. Heliyon 2020. 

Longitudinal Associations of the Cystic Fibrosis Airway Microbiome and Volatile Metabolites. Front Cell Infect Microbio 2020

Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosis.  Sci Rep 2019

Antibiotic Multidrug Resistance in the Cystic Fibrosis Airway Microbiome is Associated with Decreased Diversity. Heliyon. 2018 

Phenotypic Characterization of The c.1679+1643G>T (1811+1643G>T) Mutation in Hispanic Cystic Fibrosis Patients. Children (Basel) 2018

Benchmark Evaluation of True Single Molecular Sequencing to Determine Cystic Fibrosis Airway Microbiome Diversity.   Front Microbiol. 2018 

Relationship of Pulmonary Outcomes, Microbiology and Serum Antibiotic Concentrations in Cystic Fibrosis Patients.   J Pediatr Pharmacol Ther 2018

DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia PLoS Genet Feb 2016

Human Metapneumovirus Infection is Associated with Severe Respiratory Disease in Preschool Children with History of Prematurity. 2015 : Pediatrics and Neonatology

Increased Postoperative Respiratory Complications in Heterotaxy Congenital Heart Disease Patients with Respiratory Ciliary Dysfunction.  Journal of Thoracic and Cardiovascular Surgery 2014 

High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.   Circulation  2012